Innovation Center Prof. Dr. Yixin Zhang

Molecular biotechnology

The Innovation Center for Molecular Biotechnology conducts research at the point of contact between the biological and engineering sciences. In particular, the focus is on the study of natural events at different levels and the integration of this knowledge into methods and technologies to bridge the boundary between the life sciences and engineering.

portait of Prof. Dr. Yixin Zhang


Prof. Dr. Yixin Zhang

TU Dresden - Center for Innovation Competence for Molecular Bioengineering

Short Vita

  • Since 2016 Professor for Biomolecular Interaction at the B CUBE at TU Dresden.
  • 2009 - 2016 Junior group leader at B CUBE at TU Dresden.
  • 2004 - 2009 Research Associate at the Institute of Pharmaceutical Sciences, Department of Chemistry and Applied Biosciences, ETH Zurich
  • 2001 - 2004 Postdoc at the Max Planck Research Center for Enzymology of Protein Folding in Halle, Germany.
  • 1998 - 2001 PhD in Biochemistry at the Max Planck Research Center for Enzymology of Protein Folding in Halle, Germany
  • 1994 - 1998 Research Assistant at Shanghai Institute of Organic
  • Chemistry, Chinese Academy of Sciences
  • Studied chemistry at Shanghai University until 1994

Research and development

  • Involving biology, nanobiotechnology, and engineering Elaboration of complementary research approaches and methods.

  • Transfer of natural phenomena into innovative materials

  • Capturing potential useful natural phenomena and translating the obtained results, using biologically inspired design concepts into synthetic material.

  • Utilize current research and advances in molecular biology and translate the resulting knowledge into innovative methods, materials, and technologies of living structures.


  • DNA-encoded chemical libraries: Labeling of millions to billions of different chemical structures with DNA strands as barcodes. Thus, the selection process of biology can be mimicked to discover new bioactive compounds.
  • Develop fully automated parallel synthesis technology to enable high-throughput synthesis to meet high-throughput screening requirements.
  • Design and synthesize self-assembled biomaterials to understand the dynamics of extracellular matrices, recapitulate and model diverse biological niches, and develop novel therapeutic tools.
  • Study of isomerization of peptidyl-prolyl bond, one of the smallest chemical changes in the biological world.

Reference projects

  • Analysis of cyclophilin A binders and development of the PROTAC compound.

  • Method for developing a surface coating compatible with peptide array synthesis.

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