Innovation Center ● Prof. Dr. Yixin Zhang
Molecular biotechnology
DIRECTOR
Prof. Dr. Yixin Zhang
TU Dresden - Center for Innovation Competence for Molecular Bioengineering
Phone +49 351 463 43040
Fax +49 351 463 40322
E-mail yixin.zhang1@tu-dresden.de
Short Vita
- Since 2016 Professor for Biomolecular Interaction at the B CUBE at TU Dresden.
- 2009 - 2016 Junior group leader at B CUBE at TU Dresden.
- 2004 - 2009 Research Associate at the Institute of Pharmaceutical Sciences, Department of Chemistry and Applied Biosciences, ETH Zurich
- 2001 - 2004 Postdoc at the Max Planck Research Center for Enzymology of Protein Folding in Halle, Germany.
- 1998 - 2001 PhD in Biochemistry at the Max Planck Research Center for Enzymology of Protein Folding in Halle, Germany
- 1994 - 1998 Research Assistant at Shanghai Institute of Organic
- Chemistry, Chinese Academy of Sciences
- Studied chemistry at Shanghai University until 1994
Research and development
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Involving biology, nanobiotechnology, and engineering Elaboration of complementary research approaches and methods.
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Transfer of natural phenomena into innovative materials
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Capturing potential useful natural phenomena and translating the obtained results, using biologically inspired design concepts into synthetic material.
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Utilize current research and advances in molecular biology and translate the resulting knowledge into innovative methods, materials, and technologies of living structures.
Expertise
- DNA-encoded chemical libraries: Labeling of millions to billions of different chemical structures with DNA strands as barcodes. Thus, the selection process of biology can be mimicked to discover new bioactive compounds.
- Develop fully automated parallel synthesis technology to enable high-throughput synthesis to meet high-throughput screening requirements.
- Design and synthesize self-assembled biomaterials to understand the dynamics of extracellular matrices, recapitulate and model diverse biological niches, and develop novel therapeutic tools.
- Study of isomerization of peptidyl-prolyl bond, one of the smallest chemical changes in the biological world.
Reference projects
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Analysis of cyclophilin A binders and development of the PROTAC compound.
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Method for developing a surface coating compatible with peptide array synthesis.
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