Non-interventional studies ● 08/13/2020 ● Prof. Dr. med. habil. Dirk Koschel
Idiopathic pulmonary fibrosis
Premature mortality of IPF patients may eventually occur despite stable measurements for FVC and D LCO.
The aim was to assess the course of disease of IPF patients with and without antifibrotic therapy under real-life conditions. Data were analysed from a non-interventional, prospective cohort study of consecutively enrolled IPF patients from 20 interstitial lung disease expert centres in Germany. Among the 588 patients suitable for analysis, the mean±sd age was 69.8±9.1 years, and 81.0% were male. The mean±sd duration of disease since diagnosis was 1.8±3.4 years. The mean±sd value at baseline for forced vital capacity (FVC) and diffusion capacity (D LCO) were 68.6±18.8% predicted and 37.8±18.5% predicted, respectively. During a mean±sd follow-up of 1.2±0.7 years, 194 (33.0%) patients died. The 1-year and 2-year survival rates were 87% versus 46% and 62% versus 21%, respectively, for patients with versus without antifibrotic therapy. The risk of death was 37% lower in patients with antifibrotic therapy. The results were robust (and remained statistically significant) on multivariable analysis. Overall decline of FVC and D LCO was slow and did not differ significantly between patients with or without antifibrotic therapy. Survival was significantly higher in IPF patients with antifibrotic therapy, but the course of lung function parameters was similar in patients with and without antifibrotic therapy. This suggests that in clinical practice, premature mortality of IPF patients eventually occurs despite stable measurements for FVC and D LCO.
Survival and course of lung function in the presence or absence of antifibrotic treatment in patients with idiopathic pulmonary fibrosis: long-term results of the INSIGHTS-IPF registry. Behr J, Prasse A, Wirtz H, Koschel D, Pittrow D, et al. Eur Respir J. 2020 Aug 13;56(2):1902279.
GWT-TUD GmbH, Dresden, Germany and Department of Pneumology, Medical Clinic I, Medical Faculty, Technical University, Dresden, Germany and Department of Internal Medicine and Pneumology, Fachkrankenhaus Coswig, Germany.
Prof. Dr. med. habil. Dirk Koschel
Department of Pneumology
Medical Clinic I, Medical Faculty
Technical University Dresden
Department of Internal Medicine and Pneumology
Specialized Hospital Coswig
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